解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Clear cell sarcoma of soft tissues is a very rare, malignant soft tissue tumor that usually arises in the extremities, with a predilection for the lower limbs. This report presents a 45-year-old male with a painless mass in the right lumbar region for one year. Magnetic resonance imaging showed a 3.6×3.2×1.5-cm soft t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2372
更新日期:2014-10-01 00:00:00
abstract::DNA topoisomerase II-α (Topo II-α) is essential for numerous cell processes, including DNA replication, transcription, recombination, and chromosome separation and condensation. Altered Topo II-α expression may lead to carcinogenesis and cancer progression. The aim of the present study was to investigate the associati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2367
更新日期:2014-10-01 00:00:00
abstract::In the present study, Frizzled-2 (Fz2), a receptor of the Wnt ligand, was investigated as a potential target of molecular therapy for hepatocellular carcinoma (HCC). Quantitative polymerase chain reaction (PCR) was performed to determine the expression levels of Fz2. A surgical specimen of HCC was immunostained with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2408
更新日期:2014-10-01 00:00:00
abstract::Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor immune response. It has been confirmed that the B7-CD28 pathway may promote tumor immune evasion by providing a negative regulatory signal. Th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2356
更新日期:2014-10-01 00:00:00
abstract::The use of 5α-reductase inhibitors (5α-RIs) as prostate cancer chemoprevention agents is controversial. Two large randomized trials, the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial, have both shown a decreased incidence of prostate cancer in patient...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2388
更新日期:2014-10-01 00:00:00
abstract::The aim of this study was to investigate the characteristics of serum secreted frizzled-related protein 5 (SFRP5), an inhibitor of Wnt signaling, in hepatitis B virus (HBV)-associated infections and hepatocellular carcinoma (HCC) patients. Serum SFRP5 levels were detected in 147 patients with HBV-associated chronic in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2256
更新日期:2014-09-01 00:00:00
abstract::Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of to...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2311
更新日期:2014-09-01 00:00:00
abstract::The RAS/RAF and PI3K/PTEN signaling pathways play central roles in hepatocarcinogenesis. KRAS, NRAS, HRAS, BRAF, PIK3CA, PIK3R1 and PTEN are key cancer-related genes in the RAS/RAF and PI3K/PTEN signaling pathways. Genetic alterations in these genes often lead to the dysregulation of the two cascades. Little is known ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2253
更新日期:2014-09-01 00:00:00
abstract::The current report presents the case of a 43-year-old male suffering from a penile cutaneous horn. A surgical excision of the lesion was performed and histopathology demonstrated hyperkeratosis, dyskeratosis and epithelial hyperplasia. The cutaneous horn progressed to squamous cell carcinoma <1.5 months following surg...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2247
更新日期:2014-09-01 00:00:00
abstract::Wiskott-Aldrich syndrome protein family member 3 (WASF3) is required for invasion and metastasis in different cancer cell types, and has been demonstrated to possess prognostic value in various types of human cancer. However, to the best of our knowledge, the expression profile of WASF3 and its correlations with the c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2276
更新日期:2014-09-01 00:00:00
abstract::Synchronous or metachronous occurrence of gastrointestinal stromal tumors (GISTs) and other primary gastrointestinal neoplasms has previously been reported. However, to the best of our knowledge, there are few studies regarding metachronous multiple GISTs and adenocarcinoma of the colon. The current case of an 80-year...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2266
更新日期:2014-09-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is rare in the adult population and even rarer with jaw involvement. The current study presents the case of a 39-year-old male who complained of recurrent pain, swelling of the gingiva and an occasional pus-like discharge in the right mandible for one year. The patient was previousl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2272
更新日期:2014-09-01 00:00:00
abstract::The histological subtype of non-small-cell lung cancer (NSCLC) is a significant factor when selecting treatment strategies. However, cases are occasionally encountered that are diagnosed as 'not otherwise specified' (NOS) prior to surgery, due to an uncertain histological subtype. The present study investigated the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2302
更新日期:2014-09-01 00:00:00
abstract::The present study sought to characterize the role of macrophage inflammatory protein-3α (MIP-3α) in non-small cell lung cancer (NSCLC) patients with early recurrence or metastasis after primary pulmonary resection. Follow-up examinations were conducted for 203 NSCLC patients with primary pulmonary resection for two ye...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2229
更新日期:2014-08-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are recently identified regulators in tumorigenesis and tumour progression. BRAF-activated lncRNA (BANCR) is overexpressed in melanoma and has a potential functional role in melanoma cell migration. However, little is known concerning the role of BANCR in the development of colorectal ca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2154
更新日期:2014-08-01 00:00:00
abstract::The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2177
更新日期:2014-08-01 00:00:00
abstract::Photodynamic therapy (PDT) is a treatment modality that has clinical applications in both non-neoplastic and neoplastic diseases. PDT involves a light-sensitive compound (photosensitizer), light and molecular oxygen. This procedure may lead to several different cellular responses, including cell death. Alterations in ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2149
更新日期:2014-08-01 00:00:00
abstract::The present study aimed to screen the regulatory mechanism of microRNA (miR/miRNA) typing on gastric cancer cells in gastric cancer tissues. In total, 46 patients who underwent gastric resection in Xiangya Hospital of Central-South University (Changsha, Hunan, China) between January and December 2012 were selected. Ga...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2232
更新日期:2014-08-01 00:00:00
abstract::K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2205
更新日期:2014-08-01 00:00:00
abstract::Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2225
更新日期:2014-08-01 00:00:00
abstract::Previous studies have revealed the aberrant expression of a number of microRNAs (miRNA/miRs) in the blood circulation of patients with breast cancer (BC). The aim of the present study was to assess the effect of neoadjuvant chemotherapy on the levels of a panel of BC-associated miRNAs, which are at relatively low (let...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2188
更新日期:2014-08-01 00:00:00
abstract::Secretory breast carcinoma is a very rare and distinct subtype of breast cancer, characterized by the presence of intracellular and extracellular secretory material. Secretory breast carcinoma has a good clinical outcome and systemic involvement is rare. The majority of studies of this tumor have been case reports or ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2213
更新日期:2014-08-01 00:00:00
abstract::Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription-3 (STAT3), phosphor-STAT3 (p-STAT3), hypoxia-inducible factor-1α (HIF-1α) and VM f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2059
更新日期:2014-07-01 00:00:00
abstract::A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endotheli...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2104
更新日期:2014-07-01 00:00:00
abstract::The present study aimed to assess the feasibility, safety and efficiency of ultrasound-guided percutaneous microwave ablation (MWA) on liver metastases from colon or rectal cancer. Patients who received MWA therapy for liver metastases from colon or rectal cancer between June 2009 and May 2012 were enrolled in the stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2106
更新日期:2014-07-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical value of magnetic resonance imaging (MRI) in the preoperative T staging of gastric cancer and in the postoperative pathological diagnosis. In total, 30 patients with gastric cancer were investigated, including 19 males and 11 females (age, 50-69 years; mean age...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2135
更新日期:2014-07-01 00:00:00
abstract::Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2136
更新日期:2014-07-01 00:00:00
abstract::The epithelial cell adhesion molecule (EpCAM) is overexpressed in the majority of human epithelial carcinomas, and its overexpression is associated with proliferation and neoplastic transformation. However, the precise molecular mechanism involved in EpCAM-related proliferation and metastasis in hypopharyngeal carcino...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2140
更新日期:2014-07-01 00:00:00
abstract::The aim of the current study was to investigate the antineoplastic activities of 5-aza-2'-deoxycytidine (also known as decitabine; DAC) and all-trans retinoic acid (ATRA), administered alone or in combination, in K562 cells in vitro, as well as the effects on the expression of the tumor suppressor genes, p16INK4a (p16...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2133
更新日期:2014-07-01 00:00:00
abstract::Tumor-induced osteomalacia (TIO) is a rare acquired form of hypophosphatemia commonly associated with phosphaturic mesenchymal tumors (PMTs) located in the bone or soft tissue. Resection of the tumor can cure osteomalacia. Fibroblast growth factor 23 has been identified as a major pathophysiological factor responsible...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2081
更新日期:2014-07-01 00:00:00
abstract::Ovarian remnant syndrome (ORS) is a rare, but well-known gynecological complication, most often induced by difficult bilateral salpingo-oophorectomy (BSO) procedures that leave residual ovarian tissue on the pelvic wall. The most common preexisting conditions for this complication include endometriosis, pelvic inflamm...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2089
更新日期:2014-07-01 00:00:00
abstract::Epithelioid angiosarcoma (EA) is an extremely rare subtype of angiosarcoma, which is characterized by large cells with an epithelioid morphology. EA typically arises in deep soft tissues, including the adrenal gland, skin and thyroid, however, EA rarely arises in the spine. The current study presents a case of osteoly...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2055
更新日期:2014-06-01 00:00:00
abstract::Laparoscopic partial nephrectomy has recently emerged as a minimally invasive treatment for small- to moderate-sized renal tumors. Renal artery pseudoaneurysms (RAPs) have been well-reported in patients with renal trauma or who have undergone percutaneous urological procedures, including biopsy, nephrostomy and percut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2045
更新日期:2014-06-01 00:00:00
abstract::The present study aimed to investigate the effects of silencing RIP1 by small interfering RNA (siRNA) on the biological behavior of the LoVo human colorectal carcinoma cell line and to provide evidence for the feasibility of colorectal cancer gene therapy. LoVo cells were divided into the RIP1 siRNA group, the blank c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2040
更新日期:2014-06-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1983
更新日期:2014-06-01 00:00:00
abstract::A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor that develops or differentiates from cells in the peripheral nerve sheath. This tumor is commonly associated with neurofibromatosis type 1 (NF1) and previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare and a ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1987
更新日期:2014-06-01 00:00:00
abstract::Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract. The current study presents a case of primary EGIST of the prostate observed in a 55-year-old male. Imaging studies showed a 10×10.5×9.5-cm prostate mass. On histological observation, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1968
更新日期:2014-06-01 00:00:00
abstract::Brain-specific metastasis is one of the primary causes of recurrence following complete resection of non-small cell lung cancer (NSCLC) and the underlying mechanism remains unclear. The present study was designed to investigate the correlation between C-X-C chemokine receptor type 4 (CXCR4) expression and brain-specif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1979
更新日期:2014-06-01 00:00:00
abstract::Periosteal chondrosarcoma is an extremely rare low-grade malignant cartilaginous tumor arising from the external bone surface. Diagnosis of periosteal chondrosarcomas may be challenging, since this condition closely resembles periosteal chondromas. It has been reported that positron emission tomography (PET) is useful...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2010
更新日期:2014-06-01 00:00:00
abstract::Anaplastic thyroid carcinoma is a significantly fatal endocrine neoplasm, with an average survival time of 4-12 months following diagnosis. The present study reports the case of a 57-year-old male patient who presented to the Bağcılar Training and Research Hospital (Istanbul, Turkey) due to swelling in the neck and di...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2036
更新日期:2014-06-01 00:00:00